Set in 1921 Dublin, Ireland, 'Shake Hands with the Devil' follows Irish-American Kerry O'Shea (Don Murray), a medical student at the College of Surgeons. After fighting in World War I, Kerry wants to avoid further violence, but he is drawn into the conflict between the Irish Republican Army and the British Black and Tans after his friend Paddy Nolan (Ray McAnally) is killed. As political tensions escalate, Kerry becomes involved with Jennifer Curtis (Dana Wynter), a beautiful English hostage. Meanwhile, the British offer a peace treaty that fails to satisfy Sean Lenihan (James Cagney), the rebellious organization's leader and Kerry's former professor. Cast: - James Cagney as Sean Lenihan - Don Murray as Kerry O'Shea - Dana Wynter as Jennifer Curtis - Glynis Johns as Kitty Brady - Michael Redgrave as The General - Sybil Thorndike as Lady Fitzhugh - Cyril Cusack as Chris Noonan - Harry Brogan as Tom Cassidy - Robert Brown as First Sergeant (Black & Tans) - Lewis Casson as Judge - Christopher Casson as Brigadier - John Cairney as Mike O'Callaghan - Harry H. Corbett as Clancy (as Harry Corbett) - Allan Cuthbertson as Captain - Donal Donnelly as Willie Lafferty - Richard Harris as Terence O'Brien - William Hartnell as Sergeant Jenkins - John Le Mesurier as British General - Niall MacGinnis as Michael O'Leary - Patrick McAlinney as Donovan, bartender - Ray McAnally as Paddy Nolan - Clive Morton as Sir Arnold Fielding - Noel Purcell as Liam O'Sullivan - Peter Reynolds as Captain (Black & Tans) - Christopher Rhodes as Colonel Smithson Runtime: 111 minutes.